Reaktion #84502

Reaktionsgleichung

2-chloro-N1-(2-methyl-1-(naphthalen-2-yl)propan-2-yl)benzene-1,4-diamine

acetyl ketene

→

title compound

N-(3-chloro-4-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)phenyl)-3-oxobutanamide

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to rt
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

Vorschrift

To a solution of 2-chloro-N1-(2-methyl-1-(naphthalen-2-yl)propan-2-yl)benzene-1,4-diamine (2.0 g, 6.16 mmol) in EtOAc (30 mL) was added acetyl ketene (1.55 g, 1.84 mmol) and the mixture was stirred at 90° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (2.00 g, 79%).

Quelle