Reaktion #84474

Reaktionsgleichung

3-(3-fluoro-4-(piperazin-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one

K2CO3

3-bromoprop-1-yne

→

title compound

Ausbeute 44.1%

3-(3-fluoro-4-(4-(prop-2-yn-1-yl)piperazin-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one

Ausbeute 44.1%

Lösungsmittel

CH3CN

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was then filtered
2. 2
   Einengenthe filtrate was concentrated in vacuo
3. 3
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

Vorschrift

To a suspension of 3-(3-fluoro-4-(piperazin-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one (0.30 g, 1.00 mmol) and K2CO3 (0.69 g, 5.00 mmol) in CH3CN (15 mL) was added 3-bromoprop-1-yne (0.12 g, 1.01 mmol) and the mixture was stirred at rt for 36 h. The mixture was then filtered, and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (0.15 g, 44%). The compound was characterized by the following spectroscopic data:

Quelle