Reaktion #84465

Reaktionsgleichung

2-(piperidin-1-yl)ethanamine

K2CO3

1,2-difluoro-4-nitrobenzene

→

crude product

2-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed overnight
2. 2
   Filtrationfiltered
3. 3
   EinengenThe filtrate was concentrated in vacuo

Vorschrift

To a suspension of 2-(piperidin-1-yl)ethanamine (0.90 g, 7.02 mmol) and K2CO3 (0.97 g, 7.02 mmol) in acetone (30 mL) was added 1,2-difluoro-4-nitrobenzene (1.11 g, 6.98 mmol) in one portion in an ice bath and the mixture was refluxed overnight, cooled to rt and filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for next step without further purification.

Quelle