Reaktion #8446

ord-d179064351194b43a86982c843ec674b

Reaktionsgleichung

COc1ccc(N2CCN(C)C(=O)C2)cc1NC(N)=S
[2-methoxy-5-(4-methyl-3-oxo-piperazin-1-yl)-phenyl]-thiourea
Br.CC(=O)O
HBr AcOH
CS(C)=O
DMSO
→
COc1ccc(N2CCN(C)C(=O)C2)c2sc(N)nc12
4-(2-Amino-4-methoxy-benzothiazol-7-yl)-1-methyl-piperazin-2-one

Edukte

COc1ccc(N2CCN(C)C(=O)C2)cc1NC(N)=S
[2-methoxy-5-(4-methyl-3-oxo-piperazin-1-yl)-phenyl]-thiourea
Br.CC(=O)O
HBr AcOH
CS(C)=O
DMSO

Reagenzien

Keine

Lösungsmittel

CC(=O)O
AcOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From [2-methoxy-5-(4-methyl-3-oxo-piperazin-1-yl)-phenyl]-thiourea with HBr—AcOH (4 equiv.) and DMSO (2.4 equiv.) in AcOH. ES-MS m/e (%): 293 (M+H+, 100).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087761B2uspto-grants-2006_08