Reaktion #84402

Reaktionsgleichung

tert-butyl (2-fluoro-5-nitrophenyl)carbamate

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title compound

Ausbeute 65.0%

tert-butyl (2-fluoro-5-aminophenyl)carbamate

Ausbeute 65.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   EinengenThe filtrate was concentrated in vacuo
3. 3
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)

Vorschrift

To a solution of tert-butyl (2-fluoro-5-nitrophenyl)carbamate (3.54 g, 13.8 mmol) in MeOH (100 mL) was added catalyst 10% Pd/C (0.15 g). The reaction was stirred at rt under H2 overnight, and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as a yellowish solid (2.02 g, 65%).

Quelle