Reaktion #84382

Reaktionsgleichung

1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine

→

title compound

3-fluoro-4-(4-methylpiperazin-1-yl)aniline

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   Einengenthe filtrate was concentrated in vacuo

Vorschrift

To a solution of 1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine (14.76 g, 61.70 mmol) in THF (80 mL) was added Pd/C (3.00 g). The reaction was stirred at rt under H2 overnight. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as an offwhite solid (11.99 g, 93%).

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