Reaktion #84381

Reaktionsgleichung

1-methylpiperazine

Et3N

1,2-difluoro-4-nitrobenzene

→

title compound

Ausbeute 98.0%

1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine

Ausbeute 98.0%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at rt overnight
2. 2
   WaschenThe reaction mixture was washed with brine
3. 3
   Trocknendried over anhydrous Na2SO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of 1-methylpiperazine (6.91 g, 69 mmol) and Et3N (6.98 g, 69 mmol) in EtOAc (60 mL) was added 1,2-difluoro-4-nitrobenzene (10.02 g, 63 mmol) dropwise with stirring and the mixture was stirred at rt overnight. The reaction mixture was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (14.75 g, 98%).

Quelle