Reaktion #84375

Reaktionsgleichung

K2CO3

1,1-dioxo-thio-morpholinehydrochloride

3,4-difluoronitrobenzene

→

title compound

Ausbeute 110.1%

4-(2-fluoro-4-nitrophenyl)1,1-dioxidothiomorpholine

Ausbeute 110.1%

Lösungsmittel

DMSO

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with CH2Cl2 (100 mL×2)
2. 2
   TrocknenThe combined organic phases were dried over anhydrous Na2SO4
3. 3
   Einengenconcentrated in vacuo

Vorschrift

To a suspension of K2CO3 (5.53 g, 40 mmol) and 1,1-dioxo-thio-morpholinehydrochloride (3.60 g, 21 mmol) in DMSO (50 mL) was added 3,4-difluoronitrobenzene (3.18 g, 20 mmol). The reaction was heated at 100° C. for 12 h. The mixture was diluted with water (150 mL) and extracted with CH2Cl2 (100 mL×2). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (6.04 g, 70%).

Quelle