Reaktion #84268

Reaktionsgleichung

1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanone

trimethylphenylammonium tribromide

→

desired product

2-bromo-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanone

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Filtrationthe precipitated solid was filtered off through celite
3. 3
   Sonstigethe solvent was evaporated under reduced pressure
4. 4
   SonstigeThe resulting residue was purified by silica gel column chromatography

Vorschrift

To 0.82 g of 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanone in 10 ml of tetrahydrofuran, 1.38 g of trimethylphenylammonium tribromide was added, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, the precipitated solid was filtered off through celite, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using diethyl ether as the eluent to obtain 1.43 g of the desired product as a brown oil. The oil was used in the next step without further purification.

Quelle