Reaktion #84222

ord-90d17e8e63f24955b2916d8f9f738d7b

Reaktionsgleichung

CS(=O)(=O)Nc1cc(C(F)(F)F)c(F)cc1I
N-(4-fluoro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide
C#CC(C)(O)CSCC
1-ethylsulfanyl-2-methyl-but-3-yn-2-ol
→
CCSCC(C)(O)c1cc2cc(F)c(C(F)(F)F)cc2n1S(C)(=O)=O
title compound
CCSCC(C)(O)c1cc2cc(F)c(C(F)(F)F)cc2n1S(C)(=O)=O
1-Ethylsulfanyl-2-(5-fluoro-1-methanesulfonyl-6-trifluoromethyl-1H-indol-2-yl)-propan-2-ol

Edukte

CS(=O)(=O)Nc1cc(C(F)(F)F)c(F)cc1I
N-(4-fluoro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide
C#CC(C)(O)CSCC
1-ethylsulfanyl-2-methyl-but-3-yn-2-ol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThis compound was prepared
  2. 2
    Sonstigereacted

Vorschrift

This compound was prepared using the general Sonagashira procedure as described in the General Procedures Example C. The starting material was N-(4-fluoro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide (0.77 g, 2.0 mmol) and 1-ethylsulfanyl-2-methyl-but-3-yn-2-ol (0.29 g, 2.0 mmol), reacted to yield the title compound as a golden oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434688B2uspto-grants-2016_09