Reaktion #84206

Reaktionsgleichung

6

5-hydroxy-3-(1-naphthoyl)-N-pentyl-1H-indole

TFA

→

5-carboxymethoxy-3-(1-naphthoyl)-N-pentyl-1H-indole

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated to dryness
2. 2
   Sonstigethe crude obtained
3. 3
   Sonstigewas purified by chromatography on silica-gel
4. 4
   Sonstigeto give Hapten-B (2.1 g, 79%)

Vorschrift

To a solution of 7 (3.0 g, 6 4 mmol) in dichloromethane (50 ml) was added TFA (25 ml) and the mixture was stirred at room temperature for 3 h. The mixture was evaporated to dryness and the crude obtained was purified by chromatography on silica-gel using 5% methanol in chloroform to give Hapten-B (2.1 g, 79%).

Quelle