Reaktion #84197

Reaktionsgleichung

bromopropanol

NaOH

4-hydroxybenzoic acid

→

4-(3-hydroxypropoxy)benzoic acid

Lösungsmittel

EtOH

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter stirring for 30 minutes
2. 2
   workup.ADDITIONwas dropped
3. 3
   Sonstigereacted for 24 hours
4. 4
   Sonstigeafter elevating to 80° C
5. 5
   SonstigeA solvent was removed from a reaction product and hydrochloric acid-treatment

Vorschrift

An aqueous solution of NaOH (1 mol) and KI (0.05 mmol) was added to a solution of 4-hydroxybenzoic acid (0.5 mmol) and 400 mL EtOH solution under a nitrogen atmosphere and stirred. After stirring for 30 minutes, an EtOH solution including bromopropanol (0.55 mmol) was dropped thereinto, and then, reacted for 24 hours after elevating to 80° C. A solvent was removed from a reaction product and hydrochloric acid-treatment was carried out. A solid phase was isolated through filteration, and 4-(3-hydroxypropoxy)benzoic acid as a compound of Formula 4 was synthesized.

Quelle