Reaktion #84066

Reaktionsgleichung

4-cyanophenylboronic acid

2,4-dichloro-6-methoxyquinoline

→

desired product

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   SonstigeThe resulting solid was isolated by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried
5. 5
   Sonstigefollowed by recrystallization from methanol

Vorschrift

Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4. The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.

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