Reaktion #84048

Reaktionsgleichung

quinuclidin-3-one hydrochloride

sodium methoxide

→

title compound

Quinuclidin-3-one

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting precipitate is filtered off with suction
2. 2
   Einengenthe filtrate is concentrated in vacuo
3. 3
   SonstigeThe residue is partitioned between chloroform and water
4. 4
   Extraktionextracted with chloroform
5. 5
   TrocknenThe combined organic phases are dried over sodium sulfate
6. 6
   Einengenconcentrated in vacuo

Vorschrift

100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.

Quelle