Reaktion #84046

Reaktionsgleichung

Fmoc-Phe-Gly-NH—(CH2)6NH-Boc

trifluoroacetic acid

→

Fmoc-Phe-Gly-NH(CH2)6—NH2.TFA

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents were removed under reduced pressure
2. 2
   Sonstigethe residue dried at high vacuum

Vorschrift

Fmoc-Phe-Gly-NH—(CH2)6NH-Boc (0.7 g) was dissolved in CH2Cl2 (4 mL) at 0° C. under N2 and then trifluoroacetic acid (TFA) (4 mL) was added. The reaction mixture was allowed to warm to RT and stirred for 2 hours under N2. The solvents were removed under reduced pressure and the residue dried at high vacuum to provide 0.71 g of Fmoc-Phe-Gly-NH(CH2)6—NH2.TFA. This crude material was used to prepare without further purification.

Quelle