Reaktion #8393

Reaktionsgleichung

2-aminopyridine

6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetic acid

carbonyl diimidazole

→

title compound

Ausbeute 72.4%

6-Amino-4-(2-furyl)-N-(2-pyridyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetamide

Ausbeute 72.4%

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated to 50° C. for 3 h
2. 2
   Temperaturcooled
3. 3
   FiltrationThe resulting white solid was filtered
4. 4
   workup.ADDITIONtreated with HCl in dioxan (4-M, 1 mL)
5. 5
   workup.ADDITIONdiluted with diethyl ether
6. 6
   Filtrationfiltered

Vorschrift

A solution of 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetic acid (200 mg, 0.77 mmol) in DMF (3 mL) was treated with carbonyl diimidazole (125 mg, 0.77 mmol), stirred at room temperature for 2 h, treated with 2-aminopyridine (72 mg, 0.77 mmol), heated to 50° C. for 3 h, cooled and diluted with water. The resulting white solid was filtered, suspended in MeOH, treated with HCl in dioxan (4-M, 1 mL) diluted with diethyl ether and filtered to give the title compound (187 mg, 59%) as a yellow solid.

Quelle