Reaktion #838631

Reaktionsgleichung

ethyl Z-2-(1-hydroxy-1-methylethyl)-3-iodoacrylate

lithium aluminum hydride

→

E-2-(1-hydroxy-1-methylethyl)-3-iodoprop-2-en-1-ol

Ausbeute 75.9%

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter destroying the excess lithium aluminum hydride
2. 2
   workup.ADDITIONby adding a saturated sodium sulfate solution (30 μl)
3. 3
   Filtrationthe alumina precipitate is filtered
4. 4
   TrocknenThe filtrate, dried (MgSO4)
5. 5
   Sonstigeevaporated under reduced pressure

Vorschrift

To a solution of ethyl Z-2-(1-hydroxy-1-methylethyl)-3-iodoacrylate (II) (4.9 mmol, 1.4 g) in anhydrous ether (30 ml), lithium aluminum hydride (2.9 mmol, 0.112 g) is added. The reaction is stirred for 1 h under an inert atmosphere (argon) at room temperature (rt). After destroying the excess lithium aluminum hydride by adding a saturated sodium sulfate solution (30 μl), the alumina precipitate is filtered. The filtrate, dried (MgSO4) and evaporated under reduced pressure, gives a white residue of E-2-(1-hydroxy-1-methylethyl)-3-iodoprop-2-en-1-ol (III) (0.9 g, 75%).

Quelle