Reaktion #838623

Reaktionsgleichung

PPh3

6-Chloro-2-iodo-pyridin-3-ylamine

2,2-dimethyl-pent-4-ynoic acid ethyl ester

→

desired product

5-(3-Amino-6-chloro-pyridin-2-yl)-2,2-dimethyl-pent-4-ynoic acid ethyl ester

Lösungsmittel

NEt3

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction was stirred overnight at room temperature
2. 2
   EinengenThe reaction mixture was concentrated
3. 3
   Sonstigepurified on silica gel (0-50% EtOAc in hexanes)

Vorschrift

PdCl2 (0.200 g, 1.13 mmol), CuI (0.214 g, 1.13 mmol), and PPh3 (0.590, 2.25 mmol) were suspended in NEt3 (150 mL) and stirred under N2. 6-Chloro-2-iodo-pyridin-3-ylamine (5.7 g, 2.24 mmol) was added, followed by 2,2-dimethyl-pent-4-ynoic acid ethyl ester (5.2 g, 3.37 mmol), and the reaction was stirred overnight at room temperature. The reaction mixture was concentrated and purified on silica gel (0-50% EtOAc in hexanes) to give the desired product.

Quelle