Reaktion #838622

Reaktionsgleichung

iodine

5-Amino-2-chloropyridine

→

desired product

6-Chloro-2-iodo-pyridin-3-ylamine

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe mixture was filtered over Celite
2. 2
   Sonstigeto remove solids
3. 3
   EinengenThe filtrate was concentrated
4. 4
   Sonstigepurified on silica gel (0-50% EtOAc in hexanes)

Vorschrift

5-Amino-2-chloropyridine (5.0 g, 0.039 mol) was dissolved in EtOH (25 mL), and silver sulfate (13.3 g, 0.043 mol) and iodine (10.9 g, 0.043 mol) were added. The reaction was stirred at room temperature overnight, and then the mixture was filtered over Celite to remove solids. The filtrate was concentrated and purified on silica gel (0-50% EtOAc in hexanes) to give the desired product.

Quelle