Reaktion #83827

Reaktionsgleichung

hydrochloric acid

2-bromopropionic acid methyl ester

2-isopropylthio-3-hydroxypyridine

potassium carbonate

→

desired intermediate

2-(2-isopropylthiopyrid-3-yloxy)-propionic acid methyl ester

Lösungsmittel

ethyl acetate

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed four times with 120 ml of water and 120 ml of ethyl acetate each time
2. 2
   Trocknenthe organic phase is dried over sodium sulfate
3. 3
   Einengenconcentrated by evaporation

Vorschrift

12.3 ml of 2-bromopropionic acid methyl ester are added dropwise at room temperature to a mixture of 16.9 g of 2-isopropylthio-3-hydroxypyridine and 15.2 g of potassium carbonate in 250 ml of dimethylformamide and the batch is stirred for 75 minutes. The suspension is introduced into a mixture of ice-water (300 ml), 50 ml of 2N hydrochloric acid and 300 ml of ethyl acetate, washed four times with 120 ml of water and 120 ml of ethyl acetate each time, and the organic phase is dried over sodium sulfate and concentrated by evaporation. 25.4 g of the desired intermediate are obtained in the form of a viscous oil.

Quelle