Reaktion #83824

Reaktionsgleichung

3-benzyloxy-pyrid-2-ylsulfonamide

→

3-hydroxy-pyrid-2-ylsulfonamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 23.8 of hydrogen have been absorbed
2. 2
   Filtrationthe catalyst is filtered off
3. 3
   SonstigeAfter evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide

Vorschrift

A solution of 263.7 g of 3-benzyloxy-pyrid-2-ylsulfonamide in 2.5 of methanol is hydrogenated with the addition of 26 g of 5% Pd/C catalyst. After 23.8 of hydrogen have been absorbed, the catalyst is filtered off. After evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide remains in the form of a crystalline mass. Melting point 162°-164° C.

Quelle