Reaktion #83815

Reaktionsgleichung

3-amino-6-isopropoxy-2-methylaminopyridine

glycolic acid

→

title compound

Ausbeute 25.0%

5-Isopropoxy-2-hydroxymethyl-3methyl-3H-imidazo[4,5-b]pyridine

Ausbeute 25.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA procedure similar to that described in Preparation 43
2. 2
   Sonstigethat the product was purified by column chromatography through silica gel
3. 3
   workup.ADDITIONby volume mixture of ethyl acetate and methanol

Vorschrift

A procedure similar to that described in Preparation 43 was repeated, except that 1.90 g of 3-amino-6-isopropoxy-2-methylaminopyridine (prepared as described in Preparation 101), and 2.39 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol, to give 0.58 g of the title compound, melting at 125°-127° C.

Quelle