Reaktion #83813

Reaktionsgleichung

6-chloro-2-methylamino-3-nitropyridine

sodium hydride

ethanol

→

title compound

6-Ethoxy-2-methylamino-3-nitropyridine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA procedure similar to that described in Preparation 88
2. 2
   Sonstigeas described in Preparation 88
3. 3
   Sonstigethe resulting crude product was crystallized by trituration with ethanol

Vorschrift

A procedure similar to that described in Preparation 88 was repeated, except that 6.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.54 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 2.1 ml of ethanol and 150 ml of dimethylformamide were used. After working up the product as described in Preparation 88, the resulting crude product was crystallized by trituration with ethanol, to give 5.10 g of the title compound, melting at 101° C.

Quelle