Reaktion #83812

Reaktionsgleichung

3-amino-6-benzyloxy-2-methylaminopyridine

glycolic acid

→

title compound

Ausbeute 46.5%

5-Benzyloxy-2-hydroxymethyl-3-methyl-3H-imidazo[4,5-b]pyridine

Ausbeute 46.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA procedure similar to that described in Preparation 43
2. 2
   Sonstigewere reacted
3. 3
   Sonstigeas described in Preparation 43
4. 4
   Sonstigethe resulting crude product was purifying by column chromatography through silica gel
5. 5
   workup.ADDITIONby volume mixture of ethyl acetate and methanol as the eluent
6. 6
   Sonstigewas then crystallized by trituration with ethyl acetate

Vorschrift

A procedure similar to that described in Preparation 43 was repeated, except that 7.50 g of 3-amino-6-benzyloxy-2-methylaminopyridine (prepared as described in Preparation 93) and 7.46 g of glycolic acid were reacted. After working up the product as described in Preparation 43 , the resulting crude product was purifying by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, and was then crystallized by trituration with ethyl acetate, to give 4.10 g of the title compound, melting at 133°-135° C.

Quelle