Reaktion #83810

Reaktionsgleichung

6-chloro-2-methylamino-3-nitropyridine

sodium hydride

benzyl alcohol

→

title compound

6-Benzyloxy-2-methylamino-3-nitropyridine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA procedure similar to that described in Preparation 88
2. 2
   Sonstigeas described in Preparation 88
3. 3
   Sonstigethe resulting crude product was crystallized by trituration with isopropanol

Vorschrift

A procedure similar to that described in Preparation 88 was repeated, except that 7.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.79 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 4.3 ml of benzyl alcohol and 150 ml of dimethylformamide were used. After working up the product as described in Preparation 88, the resulting crude product was crystallized by trituration with isopropanol, to give 9.02 g of the title compound, melting at 149° C.

Quelle