Reaktion #83765

Reaktionsgleichung

4-nitrophenol

methyl bromoacetate

potassium carbonate

→

title compound

Ausbeute 74.5%

Methyl 4-nitrophenoxyacetate

Ausbeute 74.5%

Lösungsmittel

dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONAt the end of this time, the reaction mixture was freed from dimethylformamide by distillation under reduced pressure
2. 2
   SonstigeThe residue thus obtained
3. 3
   Extraktionafter which it was extracted with ethyl acetate
4. 4
   WaschenThe extract was washed with water
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   Sonstigeafter which the solvent was removed by distillation under reduced pressure
7. 7
   SonstigeThe resulting residue was crystallized by trituration with hexane

Vorschrift

A solution of 56 g of 4-nitrophenol, 90 g of methyl bromoacetate and 100 g of potassium carbonate in 500 ml of dimethylformamide was stirred at room temperature for 2 days. At the end of this time, the reaction mixture was freed from dimethylformamide by distillation under reduced pressure. The residue thus obtained was diluted with water, after which it was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, after which the solvent was removed by distillation under reduced pressure. The resulting residue was crystallized by trituration with hexane, to give 63.3 g of the title compound, melting at 98°-99° C.

Quelle