Reaktion #83635

Reaktionsgleichung

water

chlorotrimethylsilane

trans-4-hydroxycyclohexylamine hydrochloride

triethylamine

→

trans-4-Trimethylsilyloxycyclohexylamine

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted
2. 2
   WaschenThe organic phase is washed successively with water
3. 3
   TrocknenAfter drying over MgSO4 and evaporation of the solvents, 1.43 g of amine (colorless liquid)
4. 4
   Sonstigeare obtained

Vorschrift

A solution of 1.85 ml of chlorotrimethylsilane in 10 ml of CH2Cl2 is added dropwise to a solution of 2.0 g of trans-4-hydroxycyclohexylamine hydrochloride and 4.05 ml of triethylamine in 20 ml of CH2Cl2, cooled to 0° C. After stirring for 16 hours at room temperature, the mixture is hydrolyzed with water and extracted. The organic phase is washed successively with water, a 5% solution of Na2CO3 and saturated NaCl. After drying over MgSO4 and evaporation of the solvents, 1.43 g of amine (colorless liquid) are obtained.

Quelle