Reaktion #83557

Reaktionsgleichung

(5RS)-5-hydroxy-5-(2-iodo-3-methoxy-6-pyridyl)-pentanoic acid methyl ester

→

5-(2-iodo-3-methoxy-6-pyridyl)-5-oxopentanoic acid methyl ester

Ausbeute 43.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crude product is chromatographed on silica gel with hexane/0-35% ethyl acetate

Vorschrift

Under the conditions of example 16 E, 9.98 g of (5RS)-5-hydroxy-5-(2-iodo-3-methoxy-6-pyridyl)-pentanoic acid methyl ester is reacted with 43 g of manganese dioxide for 6 hours, worked up, and the crude product is chromatographed on silica gel with hexane/0-35% ethyl acetate. 4.3 g of 5-(2-iodo-3-methoxy-6-pyridyl)-5-oxopentanoic acid methyl ester of melting point 111° C. is obtained.

Quelle