Reaktion #83551

Reaktionsgleichung

3-{6-[2-(4-methoxy-carbonylphenyl)-ethyl]-3-hydroxy-2-pyridyl}-propionic acid methyl ester

(1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene

→

3-{6-[2-(4-methoxycarbonylphenyl)-ethyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester

Ausbeute 106.1%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate

Vorschrift

Under the conditions of example 1 D, 280 mg of 3-{6-[2-(4-methoxy-carbonylphenyl)-ethyl]-3-hydroxy-2-pyridyl}-propionic acid methyl ester is reacted with 220 mg of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up, and the crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate. 230 mg of 3-{6-[2-(4-methoxycarbonylphenyl)-ethyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester of melting point 59°-61° C. is obtained.

Quelle