Reaktion #83546

Reaktionsgleichung

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

4-ethinylbenzoic acid methyl ester

→

3-{3-hydroxy-6-[2-(4-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

Ausbeute 59.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate

Vorschrift

Under the conditions of example 5 A, 6.3 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 3.28 g of 4-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate. 4.1 g of 3-{3-hydroxy-6-[2-(4-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 173°-177° C. is obtained.

Quelle