Reaktion #834451

Reaktionsgleichung

3,4-(methylenedioxy)phenylacetic acid

Intermediate D1

3,4-(methylenedioxy)phenylacetic acid

THF

lithium aluminum hydride

Rochelle's salt

LiAlH4

→

2-benzo[1,3]dioxol-5-yl-ethanol

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto quench the reaction mixture
2. 2
   ExtraktionThe aqueous layer was extracted with ether (3×100 mL)
3. 3
   TrocknenThe combined organic fractions were dried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated

Vorschrift

A solution of 3,4-(methylenedioxy)phenylacetic acid (Intermediate D1) (commercially available from Aldrich) (2 g, 11 mmol) in diethyl ether (40 mL) and THF (60 mL) was treated with lithium aluminum hydride: LiAlH4 (24 mL, 1 M in ether) at rt for 16 h. Rochelle's salt solution was added to quench the reaction mixture. The aqueous layer was extracted with ether (3×100 mL). The combined organic fractions were dried over MgSO4, filtered and evaporated to give 1.8 g of 2-benzo[1,3]dioxol-5-yl-ethanol (Intermediate D2) that was sufficiently pure to be used in the next synthetic step.

Quelle