Reaktion #834360

Reaktionsgleichung

{4-[2-amino-4-(2-furyl)-5-pyrimidinyl]-2-oxo-1,2-dihydro-1-pyridinyl}acetic acid

1-hydroxybenzotriazole

3-(3′-dimethylaminopropyl)-1-ethylcarbodiimide

diethylamine hydrochloride

triethylamine

→

title compound

Ausbeute 6.2%

N1,N1-Diethyl-2-{4-[2-amino-4-(2-furyl)-5-pyrimidinyl]-2-oxo-1,2-dihydro-1-pyridinyl}acetamide

Ausbeute 6.2%

Lösungsmittel

water

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   EinengenThe organic layer was concentrated
3. 3
   Sonstigepurified by HPLC

Vorschrift

A suspension of {4-[2-amino-4-(2-furyl)-5-pyrimidinyl]-2-oxo-1,2-dihydro-1-pyridinyl}acetic acid (10 mg, 32 μmol), 1-hydroxybenzotriazole (15 mg, 98 μmol), 3-(3′-dimethylaminopropyl)-1-ethylcarbodiimide (15 mg, 96 μmol), diethylamine hydrochloride (18 mg, 164 μmol) and triethylamine (22 μl, 160 μmol) in N,N-dimethylformamide (1.0 ml) was stirred at room temperature for 17 hours. The reaction mixture was diluted with water and then extracted with ethyl acetate. The organic layer was concentrated and then purified by HPLC, to give the title compound (0.73 mg, 6%).

Quelle