Reaktion #833525

Reaktionsgleichung

Acrylic acid chloride

(4-(6-hydroxyhexyloxy)phenyl)propionic acid

N,N-dimethylaniline

dioxane

→

(4-(6-acryloyloxyhexyloxy)phenyl)propionic acid

Ausbeute 88.5%

Lösungsmittel

heptane

ethyl acetate

water

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe ethyl acetate layer was washed with water
2. 2
   Trocknendried over anhydrous magnesium sulfate
3. 3
   SonstigeThe solvent was removed by distillation from the ethyl acetate layer
4. 4
   Sonstigeto obtain solids
5. 5
   Sonstigere-precipitated

Vorschrift

Acrylic acid chloride (74.3 g) was dropped for 10 minutes to a mixture of (4-(6-hydroxyhexyloxy)phenyl)propionic acid (200 g), N,N-dimethylaniline (100 g), BHT (0.3 g), and dioxane (1,000 mL). After stirring at 60° C. for 5 hours, the reaction mixture was poured into water and stirred with addition of ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed by distillation from the ethyl acetate layer to obtain solids. The solids were dissolved in toluene and poured into plenty of heptane and re-precipitated to obtain (4-(6-acryloyloxyhexyloxy)phenyl)propionic acid (AK2: 213 g). Melting point: 64° C. to 68° C.

Quelle