Reaktion #8332

Reaktionsgleichung

(2,2-difluoro-benzo[1,3]dioxol-5-yl)-methanol

triphenylphospine

carbon tetrachloride

→

title compound

5-Chloromethyl-2,2-difluoro-benzo[1,3]dioxole

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   Filtrationfiltered
3. 3
   Waschenthe solids washed with dichloromethane
4. 4
   EinengenThe filtrate is concentrated in vacuo

Vorschrift

A solution of (2,2-difluoro-benzo[1,3]dioxol-5-yl)-methanol (1.0 g, 5.32 mmol) in carbon tetrachloride (10.6 mL) is added to polymer-supported triphenylphospine (3.5 g, 3 mmol/g, 10.6 mmol) at room temperature. The reaction is heated for 3 h at 80° C., cooled to room temperature, filtered, and the solids washed with dichloromethane. The filtrate is concentrated in vacuo to yield the title compound, 0.79 g (72%), as a clear, orange oil.

Quelle