Reaktion #832396

ord-a5efb52dc8c940339b333ee720ed8be8

Reaktionsgleichung

CC(=O)O.CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
6-chloro-17-hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione acetate
CC(=O)O.CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
6-chloro-17-hydroxy-pregna-4,6-diene-3,20-dione acetate
→
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=C(Cl)C(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
4,6-dichloro-17-hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione

Edukte

—
( I )
CC(=O)O.CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
6-chloro-17-hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione acetate
CC(=O)O.CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
6-chloro-17-hydroxy-pregna-4,6-diene-3,20-dione acetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Preferred compounds of formula (I) are 6-chloro-17-hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione acetate (cyproterone acetate) and 6-chloro-17-hydroxy-pregna-4,6-diene-3,20-dione acetate (chlormadinone acetate).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04598072uspto-grants-1986_07