Reaktion #83217

Reaktionsgleichung

2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine

sodium borohydride

→

2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

Ausbeute 77.5%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 2 hours
2. 2
   Temperaturcooled
3. 3
   ExtraktionThe separated oil was extracted with dichloromethane
4. 4
   WaschenThe extract was washed with brine
5. 5
   Sonstigedried
6. 6
   Einengenconcentrated in vacuo
7. 7
   SonstigeThe residue was crystallized from a mixture of ethyl acetate and ethyl ether

Vorschrift

A mixture of 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine (56 mg) and sodium borohydride (16 mg) in ethanol (2 ml) was refluxed for 2 hours, cooled, and poured into ice water. The separated oil was extracted with dichloromethane. The extract was washed with brine, dried and concentrated in vacuo. The residue was crystallized from a mixture of ethyl acetate and ethyl ether to yield 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (44 mg).

Quelle