Reaktion #83096

ord-e13a0f63c68d4cbe8884355f7025e3b4

Reaktionsgleichung

O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
product
O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester
CC[C@H](N)C(=O)O
L-2-aminobutyric acid
CCN(CC)CC
triethylamine
→
CC[C@H](NC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)O
desired product
Ausbeute 81.5%
CC[C@H](NC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)O
(S)-2-[[[(4-Nitrophenyl)methoxy]carbonyl]amino]butanoic Acid
Ausbeute 81.5%

Edukte

O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
product
O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester
CC[C@H](N)C(=O)O
L-2-aminobutyric acid
CCN(CC)CC
triethylamine

Reagenzien

Keine

Lösungsmittel

CCO.O
ethyl alcohol water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared by the procedure of Example 255 using 29.46 g of product from Example 254, 9.5 g of L-2-aminobutyric acid, 25.5 ml of triethylamine and 1112 ml of 4:1 ethyl alcohol/water to give 21.2 g of the desired product after chromatography.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05623081uspto-grants-1997_04