Reaktion #83094

ord-25689f53ecad44ddbac2e2808a05892a

Reaktionsgleichung

O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
product
O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester
CC(C)[C@H](N)C(=O)O
L-valine
CCN(CC)CC
triethylamine
CCO
ethyl alcohol
→
CC(C)[C@H](NC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)O
desired product
Ausbeute 35.7%
CC(C)[C@H](NC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)O
N-[[(4-Nitrophenyl)methoxy]carbonyl]-L-valine
Ausbeute 35.7%

Edukte

O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
product
O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester
CC(C)[C@H](N)C(=O)O
L-valine
CCN(CC)CC
triethylamine
CCO
ethyl alcohol

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared by the procedure of Example 255 using 14.73 g of product from Example 254, 5.42 g of L-valine, 12.75 ml of triethylamine and 556 ml of 4:1 ethyl alcohol:water to give 4.89 g of the desired product after chromatography.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05623081uspto-grants-1997_04