Reaktion #83085

ord-7ea2b407c4394b4488fa5b48b65ef21c

Reaktionsgleichung

CC(C)C[C@H](N)C(=O)O
L-leucine
O=C(Cl)OC(Cl)(Cl)Cl
diphosgene
→
CC(C)C[C@@H]1NC(=O)OC1=O
desired product
CC(C)C[C@@H]1NC(=O)OC1=O
(S)-4-(2-Methylpropyl)-2,5-oxazolidinedione

Edukte

CC(C)C[C@H](N)C(=O)O
L-leucine
O=C(Cl)OC(Cl)(Cl)Cl
diphosgene

Reagenzien

Keine

Lösungsmittel

C1CCOC1
tetrahydrofuran

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared by the procedure of Example 262 using 3.93 g of L-leucine, 2.7 ml of diphosgene, 0.075 g of activated carbon, and 40 ml of dry tetrahydrofuran to give 2.74 g of the desired product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05623081uspto-grants-1997_04