Reaktion #830221

Reaktionsgleichung

sodium hydroxide

methanol

ethyl (E)-3-phenyl-3-(4-pyridyl)-acrylate

→

title compound

Ausbeute 70.3%

(E)-3-phenyl-3-(4-pyridyl)acrylic acid

Ausbeute 70.3%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with methylene chloride
2. 2
   workup.ADDITIONSufficient hydrochloric acid was added to the aqueous phase
3. 3
   SonstigeThe resulting precipitate was collected

Vorschrift

20 ml of a 10% w/v aqueous solution of sodium hydroxide were added to 35 ml of a methanol solution containing 3,41 g of ethyl (E)-3-phenyl-3-(4-pyridyl)-acrylate (prepared as described in Preparation 2), and the mixture was stirred for 1 hour an room temperature. At the end of this time, the reaction solution was poured into 50 ml of water and washed with methylene chloride. Sufficient hydrochloric acid was added to the aqueous phase to adjust the pH to a value of 2.8. The resulting precipitate was collected, giving 2.131 g of the title compound, as a white powder, melting at 239°-241° C.

Quelle