Reaktion #82989

Reaktionsgleichung

3-Benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

p-toluenesulfonic acid monohydrate

sodium carbonate

→

ethyl 3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheating the mixture
2. 2
   Temperaturunder reflux for 8 hours
3. 3
   Einengenconcentrating the mixture under reduced pressure
4. 4
   workup.ADDITIONadding a saturated aqueous sodium bicarbonate to the reaction residue
5. 5
   Extraktionextracting it with ethyl acetate
6. 6
   Waschenwashing the extraction solution successively with water and saturated aqueous NaCl solution
7. 7
   Trocknendrying it over anhydrous magnesium sulfate
8. 8
   Einengenconcentrating the resulting solution

Vorschrift

3-Benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid (1.50 g, 6.13 mmol) was suspended in ethanol (30 ml), followed by adding p-toluenesulfonic acid monohydrate (145 mg, 0.76 mmol), heating the mixture under reflux for 8 hours, adding sodium carbonate to the reaction solution for neutralization, concentrating the mixture under reduced pressure, adding a saturated aqueous sodium bicarbonate to the reaction residue, extracting it with ethyl acetate, washing the extraction solution successively with water and saturated aqueous NaCl solution, drying it over anhydrous magnesium sulfate, concentrating the resulting solution to obtain ethyl 3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylate (1.51 g, 5.52 mmol, 90%), and recrystallizing it from ethanol to obtain a pure product.

Quelle