Reaktion #829583

Reaktionsgleichung

N-(2-Fluoro-4-chloro-5-cyclopentyloxyphenyl)-3,4,5,6-tetrahydrophthalimide

2-methylcyclohexylamine

→

N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-(2-methylcyclohexyl)-3,4,5,6-tetrahydrophthalamide

Ausbeute 28.4%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
3. 3
   Sonstigethe precipitated crystals were isolated by filtration
4. 4
   WaschenThe crystals were washed with hexane
5. 5
   Sonstigedried

Vorschrift

N-(2-Fluoro-4-chloro-5-cyclopentyloxyphenyl)-3,4,5,6-tetrahydrophthalimide (1.00 g, 2.75 mmol), 2-methylcyclohexylamine (0.620 g, 5.48 mmol) and benzene (25 ml) as a solvent were placed into a round bottom flask (50 cc) and stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure, and the precipitated crystals were isolated by filtration. The crystals were washed with hexane and dried to obtain N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-(2-methylcyclohexyl)-3,4,5,6-tetrahydrophthalamide as white crystals (0.373 g, 28.4% yield).

Quelle