Reaktion #8293

Reaktionsgleichung

4-acetoxy-3-phenyl-butyric acid methyl ester

→

title compound

4-Phenyl-dihydro-furan-2-one

Lösungsmittel

1,4-dioxane

sulfuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeVolatile solvents are evaporated
2. 2
   Extraktionthe residue is extracted with toluene
3. 3
   ExtraktionThe combined organic extracts are extracted with water and brine
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated

Vorschrift

A solution of 4-acetoxy-3-phenyl-butyric acid methyl ester, (4.5 g, 19.2 mmol) in 1,4-dioxane (29 mL) and sulfuric acid (29 mL) is stirred at room temperature for one hour then heated at 45° C. for 18 h. Volatile solvents are evaporated and the residue is extracted with toluene. The combined organic extracts are extracted with water and brine, filtered, and concentrated to yield the title compound, 2.2 g (71%), as a colorless liquid.

Quelle