Reaktion #82906

ord-01a857b0647247a5ae68bd41c6dace10

Reaktionsgleichung

O=C(Cl)CCCCC(=O)Cl
adipoyl chloride
Nc1cccc(B(O)O)c1
(3-aminophenyl)boronic acid
CC(C)COC(=O)OCC(C)C
diisobutylcarbonate
O=C(Cl)CCC(=O)Cl
succinyl chloride
CC(C)COC(=O)OCC(C)C.O=C(O)COCCOCCOCC(=O)O
3,6,9-trioxaundecanedioic acid diisobutylcarbonate
O=C(Cl)COCCOCCOCC(=O)Cl
3,6,9-trioxaundecanedioyl chloride
→
OB(O)c1ccccc1
Phenylboronic acid

Edukte

—
Formula IX
O=C(Cl)CCCCC(=O)Cl
adipoyl chloride
—
dicarboxylic acid
Nc1cccc(B(O)O)c1
(3-aminophenyl)boronic acid
CC(C)COC(=O)OCC(C)C
diisobutylcarbonate
O=C(Cl)CCC(=O)Cl
succinyl chloride
CC(C)COC(=O)OCC(C)C.O=C(O)COCCOCCOCC(=O)O
3,6,9-trioxaundecanedioic acid diisobutylcarbonate
O=C(Cl)COCCOCCOCC(=O)Cl
3,6,9-trioxaundecanedioyl chloride
—
suberoyl chloride,3,3'-dithiopropionyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Phenylboronic acid reagents of General Formula IX are prepared by condensation of (3-aminophenyl)boronic acid with an activated dicarboxylic acid preferably selected from, but not limited to, either succinyl chloride, adipoyl chloride, adiptic acid diisobutylcarbonate, suberoyl chloride,3,3'-dithiopropionyl chloride and 3,6,9-trioxaundecanedioyl chloride and 3,6,9-trioxaundecanedioic acid diisobutylcarbonate. The preparation of a single reagent of General Formula IX has been previously reported (Burnett, T. J., Peebles, H. C. and Hageman, J. H. (1980) Biochem. Biophys. Research Commun., 96, 157-162). ##STR11##

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05623055uspto-grants-1997_04