Reaktion #828867

Reaktionsgleichung

product

1-(4-Fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanol

PCC

→

title compound

Ausbeute 96.2%

1-(4-Fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone

Ausbeute 96.2%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through a short pad of silica gel (eluted with acetone)
2. 2
   EinengenThe eluant was concentrated
3. 3
   Sonstigethe residue was chromatographed on silica gel (eluted with 30 % EtOAc/CH2Cl2)

Vorschrift

To a cold (0° C.) solution of the product of step 2 (5.45 g, 18.5 mmol) in CH2C2 (350 mL) was added PCC (6.13 g, 28 mmol). The mixture was stirred at r.t. for 6.5 h and filtered through a short pad of silica gel (eluted with acetone). The eluant was concentrated and the residue was chromatographed on silica gel (eluted with 30 % EtOAc/CH2Cl2) to give 5.2 g of the title compound.

Quelle