Reaktion #828725

Reaktionsgleichung

2-isopropylthiobenzoyl chloride

3-hydroxyoxetane

pyridine

→

oxetan-3-yl 2-isopropylthiobenzoate

Ausbeute 89.0%

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe suspension formed
2. 2
   WaschenAdding water to the reaction mixture, washing the organic phase with water
3. 3
   Sonstigedrying
4. 4
   Sonstigeevaporating it

Vorschrift

A mixture of 12.9 g of 2-isopropylthiobenzoyl chloride and 20 ml of absolute toluene is added dropwise to a mixture of 4.44 g of 3-hydroxyoxetane, 6.64 g of pyridine and 60 ml of absolute toluene at a temperature of 15° to 20° C. The suspension formed is stirred at a temperature of 20°-25° C. for 2 hours and at a temperature of 40°-45° C. for a further 3 hours. Adding water to the reaction mixture, washing the organic phase with water and drying and evaporating it gives 12.6 g of oxetan-3-yl 2-isopropylthiobenzoate as a pale yellow oil.

Quelle