Reaktion #8287

Reaktionsgleichung

2-hydroxyaceto-phenone

pyridine

acetic anhydride

→

title compound

Acetic Acid 2-oxo-2-phenyl-ethyl ester

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe mixture is washed with water (200 mL) and brine (200 mL)
2. 2
   Trocknenthen dried over sodium sulfate
3. 3
   FiltrationThe mixture is filtered
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

Quelle