Reaktion #82833

Reaktionsgleichung

sodium methoxide

1-benzyl-4-ethoxycarbonylpiperidine

formamide

→

1-benzyl-4-carbamoylpiperidine

Lösungsmittel

methanol

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter stirring at 100° C. for 1 hour
2. 2
   Sonstigethe mixture was evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
4. 4
   Waschenwashed with water and brine
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Sonstigeevaporated in vacuo
7. 7
   SonstigeThe residue was recrystallized from ether

Vorschrift

To a mixture of 1-benzyl-4-ethoxycarbonylpiperidine (6.88 g) and formamide (3.71 ml) in N,N-dimethylformamide (30 ml) was added 28% sodium methoxide solution in methanol (4.0 ml) at 100° C. under stirring. After stirring at 100° C. for 1 hour, the mixture was evaporated in vacuo. The residue was dissolved in ethyl acetate and washed with water and brine and dried over magnesium sulfate, and evaporated in vacuo. The residue was recrystallized from ether to give 1-benzyl-4-carbamoylpiperidine (2.8 g).

Quelle