Reaktion #82775

Reaktionsgleichung

Benzyl pipecolate

sodium bicarbonate

→

(S)-Benzyl pipecolate

(S)-Benzyl Pipecolate

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONby treating
2. 2
   workup.DISSOLUTIONuntil dissolution of the organic material
3. 3
   ExtraktionThe aqueous layer was extracted twice with ethyl acetate
4. 4
   Trocknenthe combined organic extracts were dried with MgSO4
5. 5
   Sonstigeevaporated

Vorschrift

Benzyl pipecolate was routinely generated by treating an ethyl acetate suspension of this salt with saturated sodium bicarbonate until dissolution of the organic material. The aqueous layer was extracted twice with ethyl acetate and the combined organic extracts were dried with MgSO4 and evaporated to yield (S)-Benzyl pipecolate (15) as a pale yellow oil.

Quelle