Reaktion #82764

ord-c404773f82124ee5bfee41897b4e5629

Reaktionsgleichung

Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1
5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
c1cncc(C2CCNC2)c1
3-(3-pyrrolidinyl)pyridine
Nc1c(F)c(N2CCC(c3cccnc3)C2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1
title compound
Ausbeute 84.0%
Nc1c(F)c(N2CCC(c3cccnc3)C2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1
5-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo -7-[3-(3-pyridinyl)-1-pyrrolidinyl]-3-quinoline-carboxylic acid
Ausbeute 84.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Starting from 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (1.04 g, 3.5 mmol) and 3-(3-pyrrolidinyl)pyridine, a procedure analogous to that given in Example 1 provided the title compound (1.26 g, 84%) as a yellow solid, mp 250°14 252° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05622966uspto-grants-1997_04